Estudian la incidencia y el riesgo de demencia en la población del sur de Europa

Title: Incidence and lifetime risk of dementia and Alzheimer's disease in a Southern European population.

Abstract: Objective: To calculate both the incidence rates and the lifetime risk (LTR) of dementia and Alzheimer's disease (AD).

Methods: A two-phase case-finding procedure was implemented in a cohort of 4057 cognitively intact individuals 55+ years of age living in Zaragoza, Spain, and followed-up at 2.5 and 4.5 years. Age-and sex-specific incidence rates were calculated. A mortality-adjusted, multivariate model was used to document LTRs.

Results: The incidence rate of dementia continued to rise after the age of 90 years, but was slightly lower than in North and West European studies. Only a tendency for an increased LTR with age was observed. Thus, LTR was 19.7% for a 65-year-old woman and 20.4% at the age of 85 years, the corresponding figures for AD being 16.7% and 17.6%. The LTR of AD was higher in women and was about twice as high among illiterate individuals when compared with individuals with higher educational levels.

Conclusions: The incidence rate of dementia in this Southern European city was slightly lower than in previous studies in North-West Europe. LTR of dementia and AD seems to be slightly increased with age. The association of illiteracy with higher LTR of AD is intriguing.

Author(s): Lobo, A (Lobo, A.)1,2,3,4; Lopez-Anton, R (Lopez-Anton, R.)3; Santabarbara, J (Santabarbara, J.)3,5; de-la-Camara, C (de-la-Camara, C.)1,2,3,4; Ventura, T (Ventura, T.)2,3,4,6; Quintanilla, MA (Quintanilla, M. A.)1; Roy, JF (Roy, J. F.)3,7; Campayo, AJ (Campayo, A. J.)1,2,3,4; Lobo, E (Lobo, E.)1,3,4,5; Palomo, T (Palomo, T.)3,8; Rodriguez-Jimenez, R (Rodriguez-Jimenez, R.)3,8; Saz, P (Saz, P.)2,3; Marcos, G (Marcos, G.)3,4,5,9

Addresses:

1. Univ Zaragoza, Hosp Clin Univ, Serv Psiquiatria, E-50009 Zaragoza, Spain

2. Univ Zaragoza, Dept Med & Psychiat, E-50009 Zaragoza, Spain

3. Minist Sci & Innovat, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

4. Univ Zaragoza, Inst Aragones Ciencias Salud I CS, E-50009 Zaragoza, Spain

5. Univ Zaragoza, Dept Prevent Med & Publ Hlth, E-50009 Zaragoza, Spain

6. Univ Zaragoza, Hosp Univ Miguel Servet, E-50009 Zaragoza, Spain

7. Univ Zaragoza, Dept Psychol & Sociol, E-50009 Zaragoza, Spain

8. Hosp Univ 12 Octubre, Dept Psychiat, Madrid, Spain

9. Hosp Clin Univ, Med Records Serv, Zaragoza, Spain