Influencia del ejercicio de los maratónianos sobre la liberación de los biomarcadores cardíacos

Título original : The impact of exercise intensity on the release of cardiac biomarkers in marathon runners
Resumen : We sought to determine the influence of exercise intensity on the release of cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in amateur marathon runners. Fourteen runners completed three exercise trials of the same duration but at exercise intensities corresponding to: (a) a competitive marathon [mean +/- A SD: heart rate 159 +/- A 7 beat min(-1), finish time 202 +/- A 14 min]; (b) 95% of individual anaerobic threshold [heart rate 144 +/- A 6 beat min(-1)] and; (c) 85% of individual anaerobic threshold [heart rate 129 +/- A 5 beat min(-1)]. cTnI and NT-proBNP were assayed from blood samples collected before, 30 min and 3 h post-exercise for each trial. cTnI and NT-proBNP were not different at baseline before each trial. After exercise at 85% of individual anaerobic threshold cTnI was not significantly elevated. Conversely, cTnI was elevated after exercise at 95% of individual anaerobic threshold (0.016 mu g L(-1)) and to an even greater extent after exercise at competition intensity (0.054 mu g L(-1)). Peak post-exercise values of NT-proBNP were elevated to a similar extent after all exercise trials (P < 0.05). The upper reference limit for cTnI (0.04 mu g L(-1)) was exceeded in six subjects at competition intensity. No data for NT-proBNP surpassed its upper reference limit. Peak post-exercise values for cTnI and NT-proBNP were correlated with their respective baseline values. These data suggest exercise intensity influences the release of cTnI, but not NT-proBNP, and that competitive marathon running intensity is required for cTnI to be elevated over its upper reference limit.
Autores : Legaz-Arrese, A (Legaz-Arrese, Alejandro)2; George, K (George, Keith)3; Carranza-Garcia, LE (Enrique Carranza-Garcia, Luis)1,2; Munguia-Izquierdo, D (Munguia-Izquierdo, Diego)4; Moros-Garcia, T (Moros-Garcia, Teresa); Serrano-Ostariz, E (Serrano-Ostariz, Enrique)2
Direcciones :
1. Univ Autonoma Nuevo Leon, Fac Org Deport, San Nicolas De Los Garza 66455, Nuevo Leon, Mexico
2. Univ Zaragoza, Sect Phys Educ & Sports, Zaragoza, Spain
3. Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool L3 5UX, Merseyside, England
4. Univ Pablo Olavide, Sect Phys Educ & Sports, Seville, Spain