Lípidos en pacientes con anorexia nerviosa y cambios en la realimentación

Título: Lipid profile and cardiovascular risk in anorexia nervosa; the effect of nutritional treatment

Resumen :

Objective: The aim of this study was to explore the lipid profile in patients with anorexia nervosa (AN), and the changes with refeeding.

Methods: The sample comprised 102 AN outpatients (mean age 22.32 +/- 3.17). Blood tests, after 12-hour overnight fast, were performed before refeeding (M-0) and after weight restoration (M-1). Total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoproteins (LDL) and triglycerides (TRG) were determined and the following cardiovascular risk markers were calculated: LDL/HDL and TC/HDL ratios. These cut-off points were considered: TC < 200 mg/dl; HDL > 40 mg/dl; LDL < 100 mg/dl and TRG < 150 mg/dl.

Results: The time leading to weight restoration was 8.16 +/- 7.35 months. Considering patients with scores higher and lower than the corresponding cut-off points, chi(2)-test revealed a significant difference (M-0-M-1) in case of TC (p < 0.05) as well as between LDL/HDL0 and LDL/HDL1 (p < 0.05) and between TC/HDL0 and TC/HDL1 (p < 0.01). Significant differences were found between HDL0 and HDL1 (p < 0.01) and between TRG and TRG(1) (p < 0.01). Significant and negative associations between BMI0 and TC0 (r = -0.331; p < 0.05) and between TRG(0) and HDL0 (r = -0.387; p < 0.05) were found. The association between TRG(1) and LDL1 was significant and positive.

Discussion: Weight restoration tends to decrease the TC/HDL and LDL/HDL ratios despite a considerable percentage of patients maintain scores on the different variables of the lipid profile usually considered at risk.

Autores : Jauregui-Garrido, B.; Bolanos-Rios, P.; Santiago-Fernandez, M.J.; Jauregui-Lobera, I.

Direcciones :

1. Universidad Pablo de Olavide, Área Nutricional y Bromatología, (España)

2. Universidad Hospital Virgen del Rocio, departamento de Cardiología (España)

3. Inst Behav Sci (España)